'Wall of Stars' shines at virtual NSC Safety Congress & Expo
Itasca, IL � The National Safety Council is recognizing 60 individuals and seven organizations for their outstanding commitment to safety on its �Wall of Stars,� on display during the virtual NSC Safety Congress & Expo.... Read more.
The functional safety market is expected to register a CAGR of over 8.3% over the forecast period (2021 - 2026)
Functional safety is applicable to all industries today, and it is increasing in demand, as manufacturers and end users look to mitigate risk further. With the growing use of automated equipment for manufacturing, test, and process control, the need to avoid equipment damage, injuries, and environmental damage is more critical than ever.New York, March 04, 2021 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Functional Safety Market - Growth, Trends, COVID-19 Impact, and Forecasts (2021 - 2026)" - https://www.reportlinker.com/p06030492/?utm_source=GNW Growing demands and expectations from governments and workers have led manufacturers and suppliers to use predictable ways to achieve and design equipment to meet certain safety requirements.- The efficacy of the safety system is not based solely on regulatory and technical aspects but also an in-depth functional analysis of the organization, production processes, and the human factor. In the past, machinery safety was largely considered the cost.- However, presently, safety technologies might be seen as an investment in business productivity. Products like safety switches and relays have become common. With the adoption of integrated technologies and approaches to safety, PLCs, and safety mechanisms, too, have witnessed widespread use while having a limited impact on system engineering and planning.- Safety relays and safety controllers monitor the primary safety devices which protect personnel from accident and injury, ensuring safe stop and start functions on equipment with hazardous motion. Companies such as Omron, Rockwell, Sick, Eaton, and Pepperl+Fuchs, among others, are prominent providers of safety sensors and switches.- In today’s scenario, it is a high priority to create a safer environment for everyone close to and working on electrical equipment. With this intention, safety switches have evolved to provide more robust protection for equipment and personnel. When equipment requires maintenance, safety switches manufacturers make it quick and easy to disconnect and/or reconnect the power. With the power disconnected, operators can safely work on the equipment downstream. There’s no need to worry about coming in contact with live voltage.- Safety switches are a necessity in all industrial applications, as per the National Electrical Code (NEC) established by the National Fire Protection Association (NFPA). According to NEC article 430.102B, a safety switch must be in sight from all motors or manufacturing equipment. The NEC defines “in sight” as visible and not more than 50 feet from the equipment it controls.- The manufacturing industry has shrunk significantly due to the pandemic as the industry faced unprecedented challenges in the supply chain and procurement of raw materials, which resulted in significant losses for manufacturers. Few industries, such as food & beverage and pharmaceutical, were deemed essential by governments.- The COVID-19 outbreak and lockdown restrictions across the world have affected industrial activities across the world. Some of the effects of lockdown include supply chain disruptions, lack of availability of raw materials used in the manufacturing process, labor shortages, fluctuating prices that could cause the production of the final product to inflate and go beyond budget, shipping problems, etc. ?From the demand perspective, industries, such as oil and gas, are being challenged by the effects of the COVID-19 outbreak. Owing to this, producers have rapidly slashed capital spending and drilling programs. The pandemic has impacted the progress of several projects, resulting in pipelines getting stalled or delayed.Key Market TrendsSafety Sensors is Expected to Hold a Significant Share- Vendors such as Omron Corporation, Rockwell Automation, Inc., SICK AG, Pepperl+Fuchs, ABB Ltd., and Panasonic Electric Works Co., Ltd. (Panasonic Corporation) provides various safety sensors.- Safety Sensors are used for machine guarding/ personnel protection, for perimeter monitoring and body part protection, or protect hazardous areas. These sensors detect the presence of humans within a specified area and reduce the possibilities of accidents, which can be achieved through tripping function or presence detection.- Personnel protection is becoming important in automated processes. Wherever machines perform high-risk movements, relevant health and safety regulations must be observed. Even if the operator is momentarily distracted, crushing, shearing, and impact injuries must be prevented.- Stringent safety regulations by the government are driving the growth of the safety sensors. For instance, the specifications and safety requirements posed by the safety associations are putting pressure on end-user industries to increase their safety investments further.- For instance, the European Union (EU) strategic framework (2014–2020) for workplace health and safety integrates a series of actions to prevent occupational hazards. There is an intense concern over policies to reduce workplace accidents and enhance working conditions. Emphasis is placed on risk prevention and mitigation of the consequences of occupational hazards so that each member country of the European Union develops sustainably.- China issued new workplace safety rules in the year 2015, including the required facilities to conduct occupational hazard audits and detail their safety procedures. In India, four main legislations cover occupational safety and health at the workplace. The laws include The Factories Act (1948), The Mines Act (1952), The Mines Rules (1955), The Dock Workers (Safety, Health, and Welfare), and the Building and Other Construction Workers Act (Regulations of Employment and Conditions of Service) (1996).- Additionally, according to Safety Media, up to 1.3 million workers suffer from work-related illnesses. There are approximately 72,702 reported cases of employers experiencing non-fatal injuries while 144 workers suffered from fatal ones. Depending upon the age of the employee, the same incident or accident is more likely have a different impact on the employee. In the next few years, the population of workers aged over 55 and above is anticipated to increase considerably drawing attention of several organizations to automate their safety solutions.United States to Witness Significant Growth Rate- The United States is one of the largest markets for functional safety market globally. The country is renowned for its innovation capabilities and is at the forefront of prominent developments surrounding the emerging technologies of the Fourth Industrial Revolution. New-found shale resources in the United States and an increasing number of oil and gas projects are an additional indicator of the market potential.- Prominent vendors such as Honeywell, Rockwell, General Electric, and Banner Engineering Corp are headquartered in the country. In July 2020, Rockwell Automation announced a new family of safety controllers with key features to increase performance. The new SIL 3 controllers are an addition to Rockwell Automation’s GuardLogix 5380 series.- The government is also focusing on increasing its energy generation capacity, and the American government is investing in such projects. For instance, in July 2019, the US DOE (Department of Energy) announced the funding of USD 16 million for 14 tribal energy infrastructure deployment projects. And they also announced their plan to develop an environmental impact statement (EIS) to study the impacts of building a versatile nuclear test reactor in the United States.- With the increasing stringency in the government regulations, the organization is concentrating on monitoring and control its carbon emission per product, which is expected to drive the demand for fire and gas monitoring systems in the country. There are currently over 20 major upcoming water treatment construction projects across the United States, each worth USD 5 billion on average.- PLCs are widely applied in the upstream, midstream, and downstream oil and gas sectors in the United States. In the upstre... Read more.
Truecaller developer launches personal safety app Guardians that allows users to share location
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Bellicum Announces First Reported Use of CaspaCIDe? Safety Switch to Mitigate CAR - T Cell Toxicity
HOUSTON, March 04, 2021 (GLOBE NEWSWIRE) -- Bellicum Pharmaceuticals, Inc. (NASDAQ:BLCM), a leader in developing novel, controllable cellular immunotherapies for cancers, today announced the publication of a case report using the company’s CaspaCIDe (inducible caspase-9, or iC9) safety switch. The letter to the editor titled “Utility of Safety Switch to Abrogate CD 19 CAR T Cell-Associated Neurotoxicity” appeared as an ahead-of-print publication in the digital edition of Blood, a journal published by The American Society of Hematology. Link to article. The publication detailed a case report from an investigator-sponsored trial (IST) at the University of North Carolina Lineberger Comprehensive Cancer Center, where a Phase 1/2 trial is ongoing to test the safety and efficacy of autologous T lymphocytes genetically modified to express a CD19 chimeric antigen receptor (CAR) and iC9. A patient in the dose expansion cohort of this trial experienced a high grade neurologic adverse event with persistence of grade 3-4 immune effector cell-associated neurotoxicity syndrome (ICANS) for 72 hours despite standard care, and rimiducid was subsequently given per protocol to activate iC9. Within twelve hours of rimiducid administration, ICANS grade improved from 3 to 1 and was fully resolved after four days. This publication marked the first reported clinical use of the iC9 safety switch to mitigate a severe CAR-T-mediated adverse event refractory to standard of care treatment. “Given the risks of ICANS and other CAR-T cell-mediated adverse events, the inclusion of the iC9 switch has the potential to dramatically improve the safety of cellular immunotherapies,” said Matthew Foster, M.D., University of North Carolina Lineberger Comprehensive Cancer Center. “We are also encouraged by the anti-leukemic response we observed in this patient even with the use of the iC9 switch.” “We remain enthusiastic about our switch technology, which as shown in this case report and in the extensive CaspaCIDe experience from the rivo-cel program, can improve the overall benefit/risk profile of cell therapy,” said Rick Fair, President and CEO of Bellicum Pharmaceuticals. “We believe this clinical experience validates our continued efforts to incorporate this technology into a growing number of internal and collaborator programs.” About CaspaCIDe® CaspaCIDe (inducible caspase-9, or iC9) is Bellicum’s chemical induction of dimerization (CID) safety switch technology designated to eliminate cells in the event of toxicity. The CaspaCIDe switch consists of the CID-binding domain coupled to the signaling domain of caspase-9, an enzyme that is part of the apoptotic pathway. Infusion of rimiducid is designed to trigger activation of this domain of caspase-9, which in turn leads to selective apoptosis of the CaspaCIDe-containing cells. Because CaspaCIDe is designed to be permanently incorporated into Bellicum’s cellular therapies, the safety switch has the potential to be available for use long after the initial therapy is delivered. About Bellicum Pharmaceuticals Bellicum is a clinical stage biopharmaceutical company striving to deliver cures through controllable cell therapies. The company’s next-generation product candidates are differentiated by powerful cell signaling technologies designed to produce more effective CAR-T cell therapies. Bellicum’s GoCAR-T® product candidates, BPX-601 and BPX-603, are designed to be more efficacious CAR-T cell products capable of overriding key immune inhibitory mechanisms. More information about Bellicum can be found at www.bellicum.com. Forward-Looking Statements This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Bellicum may, in some cases, use terms such as “predicts,” “believes,” “potential,” “proposed,” “continue,” “designed,” “estimates,” “anticipates,” “expects,” “plans,” “intends,” “may,” “could,” “might,” “will,” “should” or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: the potential for the CaspaCIDe safety switch and rimiducid to improve safety of cell therapies; and the potential useful life of the CaspaCIDe safety switch. Various factors may cause differences between Bellicum’s expectations and actual results as discussed in greater detail under the heading “Risk Factors” in Bellicum’s filings with the Securities and Exchange Commission, including without limitation Bellicum’s quarterly report on Form 10-Q for the three months ended September 30, 2020 and Bellicum’s annual report on Form 10-K the year ended December 31, 2019. Any forward-looking statements that Bellicum makes in this press release speak only as of the date of this press release. Bellicum assumes no obligation to update our forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release. Source: Bellicum Pharmaceuticals Investors: Robert H. UhlManaging DirectorWestwicke [email protected]... Read more.
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Pharmacovigilance and Drug Safety Software Markets: Adverse Event Reporting Software, Drug Safety Audits Software, Issue Tracking Software, Fully Integrated Software - Global Forecast to 2026 - ResearchAndMarkets.com
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